PYRIDAZINONE, OXADIAZINONE, THIADIAZINONE AND TRIAZINONE CARDIOTONIC AGENTS

摘要

Disclosed are new heterocyclic compounds of formula I: (see fig. I) in which Het represents one of the following groups; (see fig. II) or (see fig. III) or (see fig. IV) wherein R11, R13 and R14 independently represents hydrogen or lower alkyl, Z represents S, O or NH; A represents a valency bond, -CH=CH- or -CH2-CH2-; R1 and R2 independently represents nitro, cyano, halogen, amino, carboxamido, aryl, aroyl, pyridyl, alkoxycarbonyl, acyl or one of following groups; (see fig. V) or (see fig. VI) or -COCH2COOR8 wherein R6 represents hydrogen or lower alkyl, R8 represents lower alkyl, R7 represents cyano or COOR10, R10 being hydrogen or a lower alkyl; or R1 and R2 together form a substituted or unsubstituted 5 or 6 membered ring which may contain 1 or 2 heteroatom N; R3, R4, and R5 represents independently hydrogen, hydroxy or lower alkyl and Y represents N or CH. These compounds may be used in the treatment of congestive heart failure.