发明名称 |
Antipsychotic benzimidazole derivatives |
摘要 |
PCT No. PCT/GB94/00607 Sec. 371 Date Dec. 20, 1995 Sec. 102(e) Date Dec. 20, 1995 PCT Filed Mar. 23, 1994 PCT Pub. No. WO94/22839 PCT Pub. Date Oct. 13, 1994A class of benzimidazole derivatives, substituted at the 2-position by a substituted piperazinylmethyl or piperazinylethyl moiety, are antagonists of dopamine receptor subtypes within the brain, having a selective affinity for the dopamine D4 receptor subtype over other dopamine receptor subtypes, and are accordingly of benefit in the treatment and/or prevention of psychotic disorders such as schizophrenia whilst manifesting fewer side-effects than those associated with classical neuroleptic drugs.
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申请公布号 |
US5792768(A) |
申请公布日期 |
1998.08.11 |
申请号 |
US19950525696 |
申请日期 |
1995.12.20 |
申请人 |
MERCK, SHARP & DOHME LIMITED |
发明人 |
KULAGOWSKI, JANUSZ JOZEF;LEESON, PAUL DAVID |
分类号 |
A61K31/495;A61K31/496;A61P25/18;C07D235/14;C07D401/12;C07D403/12;C07D409/12;(IPC1-7):A61K31/495;C07D403/06 |
主分类号 |
A61K31/495 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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