发明名称 |
Protein-polycation nucleic acid complexes and methods of use |
摘要 |
The invention relates to a system for transporting nucleic acids into the cell, which is effected by receptor-mediated endocytosis. Using a transferrin-polycation conjugate, a complex can be formed with the polyanionic nucleic acid. This complex is bound to the transferrin receptor, which is highly regulated in growing cells, and absorbed into the cell. Suitable nucleic acids include those which inhibit specific genes or the RNA function, such as antisense oligonucleotides or ribozymes or the genes coding for them. The invention further relates to a process for introducing nucleic acids into the cells, transferrin-polycation/nucleic acid complexes and pharmaceutical preparations containing them.
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申请公布号 |
US5792645(A) |
申请公布日期 |
1998.08.11 |
申请号 |
US19940254888 |
申请日期 |
1994.06.06 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
BEUG, HARTMUT;BIRNSTIEL, MAX L.;COTTEN, MATTHEW;WAGNER, ERNST |
分类号 |
C12N15/09;A61K38/00;A61K47/48;A61P31/12;A61P35/00;C07K17/08;C07K19/00;C12N15/64;C12N15/87;C12Q1/68;(IPC1-7):C12N5/16;C07K17/06 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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