发明名称 |
Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic or native, vascular grafts |
摘要 |
An apparatus and method for sterilizing, seeding, culturing, storing, shipping, and testing vascular grafts is disclosed. Specifically, the present invention relates to an apparatus and method for seeding and culturing vascular grafts with human cells. The apparatus includes a fluid reservoir, a pump, an alternating pressure source, and at least one treatment chamber. By alternating pressure to a support structure within the treatment chamber upon which a vascular graft scaffold is positioned, a varying radial stress is placed on the scaffold. In an alternative embodiment, fluid is pumped directly through the vascular graft subjecting the vascular graft to radial and shear stresses. Applying shear and/or radial stresses to the vascular graft during seeding and culturing simulates physiological conditions.
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申请公布号 |
US5792603(A) |
申请公布日期 |
1998.08.11 |
申请号 |
US19960672697 |
申请日期 |
1996.06.27 |
申请人 |
ADVANCED TISSUE SCIENCES, INC. |
发明人 |
DUNKELMAN, NOUSHIN;PETERSON, ALVIN E.;LANDEEN, LEE KEVIN;ZELTINGER, JOAN |
分类号 |
C12M3/00;A61F2/06;A61L2/24;A61L27/50;C12N5/06;C12N5/08;(IPC1-7):C12M3/00 |
主分类号 |
C12M3/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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