发明名称 |
Microparticles for delivery of nucleic acid |
摘要 |
Disclosed is a preparation of microparticles made up of a polymeric matrix and a nucleic acid expression vector. The polymeric matrix includes one or more synthetic polymers having a solubility in water of less than about 1 mg/1. At least 90% of the microparticles have a diameter less than about 100 microns. The nucleic acid is either RNA, at least 50% of which is in the form of closed circles, or circular DNA plasmid molecules, at least 50% of which are supercoiled. |
申请公布号 |
AU6250698(A) |
申请公布日期 |
1998.08.07 |
申请号 |
AU19980062506 |
申请日期 |
1998.01.22 |
申请人 |
PANGAEA PHARMACEUTICALS, INC. |
发明人 |
MARY LYNNE HEDLEY;JOANNE M. CURLEY;ROBERT S. LANGER;LYNN B. LUNSFORD |
分类号 |
C12N15/09;A61K9/16;A61K31/7088;A61K48/00;C12N5/10;C12N15/11;C12N15/87 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|