Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors)

摘要

The present invention provides a method of treatment of fungal infection with an antifungal topoisomerase I inhibitor of the formula: wherein Ar is (C6-C12)aryl, a (5- to 12-membered) heteroaryl comprising 1-3 N, S or non-peroxide O, wherein N is unsubstituted or is substituted with H, (C1-C4)alkyl or benzyl; or benzo; X is H, CN, CHO, OH, acetyl, CF3, O(C1-C4)alkyl, NO2, NH2, halogen or halo-(C1-C4)alkyl; each Y is individually H, (C1-C4)alkyl or aralkyl; Y' is H or (C1-C4)alkyl; n is 0 or 1; and each Z is individually H, (C1-C4)alkyl, halogen or halo(C1-C4)alkyl; or a pharmaceutically acceptable salt thereof.