发明名称 1-PHENYL-4-BENZYLPIPERAZINES: DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS (D4)
摘要 Disclosed are compounds of formula (I) or the pharmaceutically acceptable addition salts thereof wherein: R1 is halogen or C1-C4 alkyl; and R2 and R3 are the same or different and represent hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, alkylthio, hydroxy, amino, mono(C1-C4)alkylamino, di(C1-C4)alkylamino, or R2 and R3 together represent a 4 carbon alkenylene moiety that together with the phenyl ring to which they are attached form a naphthyl moiety, which compounds are dopamine D4(ant)agonists and useful in the treatment of neuropsychological diseases such as schizophrenia, psychotic depression and mania.
申请公布号 WO9833784(A1) 申请公布日期 1998.08.06
申请号 WO1998US01628 申请日期 1998.01.29
申请人 NEUROGEN CORPORATION;THURKAUF, ANDREW;CHEN, XI 发明人 THURKAUF, ANDREW;CHEN, XI
分类号 C07D295/06;A61K31/495;A61P25/18;A61P43/00;C07D241/04;C07D295/073;C07D295/08;C07D295/096;C07D295/112;C07D295/135;C07D317/58;C07D319/18;(IPC1-7):C07D295/06;C07D405/10 主分类号 C07D295/06
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