| 发明名称 |
MATRIX METALLOPROTEINASE INHIBITORS |
| 摘要 |
A compound of formula (I), wherein W is -NHOH or -OH, R1 is either free or protected hydroxymethyl or mercaptomethyl or derivatives thereof, R2 is free or protected hydroxy, R3 and R4 is an organic group, R5 is hydrogen or methyl, or R4 and R5, together with the nitrogen atom to which they are attached, constitute an azaheterocyclyl group, and the solvates, hydrates and pharmaceutically acceptable salts thereof, can inhibit matrix metalloproteinases and the release of tumour necrosis factor (TNF). Processes for producing the compound, intermediates involved in the processes, and pharmaceutical compositions containing the compound are also described.
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| 申请公布号 |
WO9833788(A1) |
申请公布日期 |
1998.08.06 |
| 申请号 |
WO1998EP00531 |
申请日期 |
1998.01.23 |
| 申请人 |
PHARMACIA & UPJOHN S.P.A.;ALPEGIANI, MARCO;PALLADINO, MASSIMILIANO;CORIGLI, RICCARDO;JABES, DANIELA;PERRONE, ETTORE;ABRATE, FRANCESCA;BISSOLINO, PIERLUIGI;LOMBROSO, MARINA |
发明人 |
ALPEGIANI, MARCO;PALLADINO, MASSIMILIANO;CORIGLI, RICCARDO;JABES, DANIELA;PERRONE, ETTORE;ABRATE, FRANCESCA;BISSOLINO, PIERLUIGI;LOMBROSO, MARINA |
| 分类号 |
C07D295/12;A61K31/16;A61K31/165;A61K31/221;A61K31/27;A61K31/336;A61K31/351;A61K31/357;A61K31/36;A61K31/366;A61K31/381;A61K31/41;A61K31/426;A61K31/439;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/4439;A61K31/4453;A61K31/4468;A61K31/47;A61K31/472;A61K31/5375;A61P19/02;A61P29/00;A61P35/00;A61P35/04;A61P37/00;A61P43/00;C07C69/34;C07C69/675;C07C259/06;C07C259/08;C07D211/58;C07D213/40;C07D213/55;C07D213/56;C07D213/65;C07D213/70;C07D213/75;C07D215/12;C07D215/38;C07D217/02;C07D217/04;C07D217/16;C07D217/22;C07D233/54;C07D237/02;C07D257/04;C07D277/20;C07D277/30;C07D277/44;C07D295/18;C07D295/185;C07D303/40;C07D303/48;C07D305/12;C07D307/33;C07D309/12;C07D311/20;C07D317/30;C07D317/34;C07D317/58;C07D317/66;C07D333/34;C07D405/12;C07D417/12;C07D453/02;C07D491/04;(IPC1-7):C07D309/12;C07C271/24;A61K31/22;A61K31/395 |
主分类号 |
C07D295/12 |
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