| 摘要 |
<p>A chemical synthesis apparatus (20) for building chemical compounds including a head assembly (21) having an array of movable nozzles coupled to reservoirs of liquid reagents and a base assembly having an array of reaction wells (26) is described. A transport mechanism aligns selected nozzle columns (41) in the X-direction, independently controllable sliders (100) move nozzle columns (41) in the Y-direction. The first sliding seal (30) and the plurality of second sliding seals (120) form enclosed reaction wells while permitting reagent delivery. A gas inlet (70) and outlet (71) sweep away fumes emitted by reagents. Methods of compound synthesis from chemical components are also provided. The apparatus permits the synthesis of chemical libraries.</p> |
