摘要 |
<p>An immunogenic composition capable of producing a respiratory syncytial (RS) virus specific immune response in a host immunized therewith comprises purified, inactivated RS virus which is substantially free from cellular and serum components and which is non-infectious, non-immunopotentiating, immunogenic and protective. The virus is grown on a vaccine quality cell line and harvested virus is purified under non-denaturing conditions to be substantially free from cellular and serum components. The purified RS virus is inactivated using beta-propiolactone, a non-ionic detergent, particularly n-octyl-alpha-D-glucopyranoside and n-octyl-beta-D-glucopyranoside, or ascorbic acid. The immunogenic composition may be formulated as a vaccine for in vivo administration to a human host. The immunogenic composition also may be used in diagnostic applications.</p> |
申请人 |
CONNAUGHT LABORATORIES LTD., WILLOWDALE, ONTARIO, CA |
发明人 |
SANHUEZA, SONIA E., WILLOWDALE, ONTARIO M2R 2S5, CA;EWASYSHYN, MARY ELIZABETH, WILLOWDALE, ONTARIO M2R 3N7, CA;KLEIN, MICHEL HENRI, WILLOWDALE, ONTARIO M2P 1B9, CA |