IN SITU IDENTIFICATION OF TARGET STRUCTURES E.G. IN VIVO SELECTION METHOD FOR A PHAGE LIBRARY

摘要

The invention relates to a selection method and the products resulting from the method, according to which one or more binding structures against a target structure is obtained by means of a first library of one or more binding structures linked to genetic and/or other identifying information. The method comprises the steps of reacting a first library with the displayed target structure to bind some of the binding structures to the displayed target structure, separating the displayed target structure and bound binding structures from unbound binding structures, recovering bound or unbound binding structures, and amplifying bound or unbound binding structures to create a second enriched library of binding structures. Identified binding structures are directed to target structures which are displayed in vivo and/or in situ.