Methods for preparation and use of 1A,24(S)-dihydroxy vitamin D2
摘要
1 alpha ,24(S)-Dihydroxy vitamin D2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1 alpha ,24(S)-dihydroxy vitamin D2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D2 which is converted in six steps to 1 alpha ,24(S)-dihydroxy vitamin D2. The syntheses also produced novel intermediates.
申请公布号
US5789397(A)
申请公布日期
1998.08.04
申请号
US19950485184
申请日期
1995.06.07
申请人
BONE CARE INTERNATIONAL, INC.
发明人
BISHOP, CHARLES W.;JONES, GLENVILLE;HORST, RONALD L.;KOSZEWSKI, NICHOLAS J.;KNUTSON, JOYCE C.;PENMASTA, RAJU;MORIARTY, ROBERT M.;STRUGNELL, STEPHEN;REINHARDT, TIMOTHY A.;GUO, LIANG;SINGHAL, SANJAY K.;ZHAO, LEI