发明名称 |
Treatment of endotoxin-associated disorders with cationic peptides |
摘要 |
A method for the microbial production of a cationic peptide having anti-microbial activity is provided, wherein the cationic peptide is first produced as a fusion protein having an anionic portion for suppressing the antimicrobial activity of the cationic portion. A novel cationic peptide having anti-microbial activity and LPS-binding activity is also provided. Such peptides are useful for suppressing the growth of bacteria and for the treatment of endotoxemia-associated disorders.
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申请公布号 |
US5789377(A) |
申请公布日期 |
1998.08.04 |
申请号 |
US19950405234 |
申请日期 |
1995.03.13 |
申请人 |
UNIVERSITY OF BRITISH COLUMBIA |
发明人 |
HANCOCK, ROBERT E. W.;PIERS, KEVIN L.;BROWN, MELISSA H.;KELLY, NIAMH |
分类号 |
C12N15/09;A61K38/00;A61K38/55;A61P7/00;C07K7/62;C07K14/435;C07K14/47;C07K19/00;C12N1/21;C12N9/10;C12N15/62;C12P21/02;C12R1/19;C12R1/445;(IPC1-7):A61K38/16 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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