Benzoylethylene derivative

摘要

PCT No. PCT/JP95/01475 Sec. 371 Date Jun. 25, 1996 Sec. 102(e) Date Jun. 25, 1996 PCT Filed Jul. 25, 1995 PCT Pub. No. WO96/03364 PCT Pub. Date Feb. 8, 1996Disclosed is a benzoylethylene derivative represented by the following formula (I) or a salt thereof. <IMAGE> (I) R1 to R5: a hydrogen atom, -OR9 (R9: a hydrogen atom, a C1-C5 alkyl group, etc.), etc., R6: a hydrogen atom, a C1-C5 alkyl group, etc., R7: a hydrogen atom, a cyano group, a C1-C5 alkyl group, -SOqR15 (q: 0, 1, 2, R15: a thienyl group, a phenyl group, etc.) etc., R8: a cyano group, -CR22R23X (R22, R23: a hydrogen atom, a C1-C5 alkyl group, etc., X: -NR24R25 (R24, R25: a C1-C5 alkyl group, etc., an alkylene group by combining, etc.)), etc. The benzoylethylene derivative of the present invention has potent tyrosine kinase inhibiting activity and cancer cell growth inhibiting activity. The tyrosine kinase inhibitor of the present invention is useful as a carcinostatic agent.