Use of peptide(s) for facilitating or modulating attachment of adenovirus to cells

摘要

Use of a peptide (I) homologous or identical with /- 6 consecutive amino acids of one of the sequences (S1)-(S5) to allow, or facilitate, attachment of an adenovirus (Ad) to a host cell and/or entry of Ad into the cell is new: LRAYLEGTCVEWLRRYLQNGKETLQ (S1) NSHPIQWNAPQPSHISKTILRWRPKN (S2) VKVTIMWTPPESAVTGYRVDVIPVN (S3) STVLVRWTPPRAQITGYRLTVGLTR (S4) NSLLVSWQPPRARITGYIIKYEKPS (S5) Also new are: (1) cells that express (I); (2) ligands (II) homologous or identical with /- 6 consecutive amino acids of the sequences (S6) or (S7): RAIVGFRVQWLRRYFVNGSR (S6) RHILWTPANTPAMGYLARVS (S7).