| 摘要 |
<p>The invention relates to new indole derivatives which areantagonists of excitation amino acids, to their salts ormetabolically labile esters and to methods for their preparationand application in medicine. The compounds have the generalformulawhere: R is a group selected from halogen, alkyl, alkoxy, amino,alkylamino, dialkylamino, hydroxy, trifluoromethyl,trifluoromethoxy, nitro, cyano, SO2R2 or COR2 where R2 meanshydroxy, methoxy, amino, alkylamino or dialkylamino, m has thevalue of 0 or is an integer 1 or 2, R1 is cycloalkyl, cycloalkylwith bridge bond, heteroaryl, heterocyclic phenyl with bridge bondor optionally substituted phenyl or condensed bicylic carbocyclicgroup, A means C1-C4 alkylene chain or the cahin (CH2)pY(CH2)qwhere Y is 0, S(0) or NR3, and which chains can be substituted byone or more groups selected from C1-C6 alkyl, optionallysubstituted by hydroxy, amino, alkylamino or dialkylamino, orwhich chains can be substituted by =0; R3 is hydrogen, alkyl orone nitrogenprotection group; n has the value of 0 or an integerfrom 1 to 2; p is 0 or an integer from 1 to 3 and q is 0 or aninteger from 1 to 3 provided that the sum of p+q is equal to 1, 2or 3.15 claims</p> |
