Cleavage process of cephalosporin prodrug esters in 7-amino-3-methoxymethylceph-3-em-4-carboxylic acid.
摘要
<p>The present invention relates to a process for the preparation of 7-amino-3-methoxymethylceph-3-em-4-carboxylic acid (I) from 7-amino-3-methoxymethylceph-3-em-4-carboxylic acid esters (II) or their salts by ester cleavage. The process is characterised in that the compound II is treated with formic acid, trifluoroacetic acid, methanesulphonic acid or trifluoromethanesulphonic acid or a mixture of two of these acids in each case.</p>
