| 摘要 |
Neurotrophic and antiproliferative compounds related to the antiepileptic drug valproate of general formula (I), wherein R1 is -CCH, -CH=CH2 or -CH2-CH3, R2 is a saturated, unsaturated, branched or unbranched C1-C30 alkyl group which is optionally substituted with a C3-C9 aliphatic or aromatic cyclohydrocarbon,or heterocyclic group. M is a hydrogen or a metal atom. Formula (I) is not 2-n-propyl-4-pentynoic acid (4-yn-VPA) or 2-n-propyl-4-pentenoic acid (4-en-VPA) and when R1 is -CH2-CH3, R2 is C5 to C30. This invention also provides a method of making the compounds of the invention. The compounds are useful for promoting neuronal function as in neurodegenerative disorders and for treating neoplastic disease.
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