发明名称 |
INACTIVATED RESPIRATORY SYNCYTIAL VIRAL VACCINES |
摘要 |
<p>An immunogenic composition capable of producing a respiratory syncytial (RS) virus specific immune response in a host immunized therewith comprises purified, inactivated RS virus which is substantially free from cellular and serum components and which is non-infectious, non-immunopotentiating, immunogenic and protective. The virus is grown on a vaccine quality cell line and harvested virus is purified under non-denaturing conditions to be substantially free from cellular and serum components. The purified RS virus is inactivated using beta-propiolactone, a non-ionic detergent, particularly n-octyl-alpha-D-glucopyranoside and n-octyl-beta-D-glucopyranoside, or ascorbic acid. The immunogenic composition may be formulated as a vaccine for in vivo administration to a human host. The immunogenic composition also may be used in diagnostic applications.</p> |
申请公布号 |
GR3026619(T3) |
申请公布日期 |
1998.07.31 |
申请号 |
GR19980400815T |
申请日期 |
1998.04.10 |
申请人 |
CONNAUGHT LABORATORIES LIMITED |
发明人 |
SANHUEZA, SONIA E.;EWASYSHYN, MARY ELIZABETH;KLEIN, MICHEL HENRI |
分类号 |
A61K39/155;A61P31/12;C12N7/02;C12N7/04;C12N7/06;G01N33/569;(IPC1-7):A61K39/155 |
主分类号 |
A61K39/155 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|