Human geranylgeranyl pyrophosphate synthethase

摘要

A human geranylgeranyl pyrophosphate synthetase polypeptide and DNA (RNA) encoding such polypeptide and procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for controlling morphology of cells. Antagonist against such polypeptides and their use as a therapeutic to treat cancer is also disclosed. Diagnostic assays are also disclosed which detect the presence of a mutated form of hGGPS and over-expression of the hGGPS protein.