发明名称 |
Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450 2C subfamily |
摘要 |
The invention provides two novel members of the cytochrome P450 2C subfamily of enzymes, designated 2C18 and 2C19. DNA segments encoding these enzymes are also provided. The 2C19 polypeptide represents the principal human determinant of human S-mephenytoin 4'-hydroxylase activity. The invention also provides methods of identifying drugs metabolized by S-mephenytoin 4'-hydroxylase activity. Drugs shown to be metabolized by this activity should in general not be administered to individuals having, or belong to an ethnic group at risk of, a polymorphic deficiency in S-mephenytoin 4'-hydroxylase activity.
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申请公布号 |
US5786191(A) |
申请公布日期 |
1998.07.28 |
申请号 |
US19940201118 |
申请日期 |
1994.02.22 |
申请人 |
GOLDSTEIN, JOYCE A.;ROMKES-SPARKS, MARJORIE |
发明人 |
GOLDSTEIN, JOYCE A.;ROMKES-SPARKS, MARJORIE |
分类号 |
C12N9/02;(IPC1-7):C12N9/02;C12N1/20;C12P21/06;C07H19/00 |
主分类号 |
C12N9/02 |
代理机构 |
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