C-GLYCOSIDE DERIVATIVE

摘要

PROBLEM TO BE SOLVED: To obtain the subject new chemically and physiologically stable compound having a substituted amide group at the 6-position, having an excellent cell adhesion-inhibiting activity. SOLUTION: A compound of formula I (R<1> is a 1-18C alkyl, phenyl(1-12C) alkyl; R<2> , R<3> are each D-galactopyranosyl, L-fucopyranosyl; R<4> is a 1-6C alyl, an aromatic heterocyclic group, etc.), e.g. (α-L-fucopyranosyl-(1→4)-0-[(β-D- galactosylphyranosyl)-(1→3)-0]-(6-naphthamido-1α-propyl-1,2,6-trideoxy-D- alabinohexopyranose). The compound is obtained e.g. by successively applying a reaction with a carbon-nucleophilic agent, a hydrolysis reaction, etc., to a compound of formula II (R<5> is an aroyl, benzyl, etc.; Z<1> is a releasable group), reacting the product with a compound of formula III (R<10> is benzyl; Z<2> is Z<1> ), applying a protecting group-removing reaction, a hydrolysis reaction, etc., to the reaction product, reacting the product with a compound of formula IV (R<12> is aroyl, etc.; Z<3> is Z<1> ), and further applying a protecting group-removing reaction, etc., to the reaction product.