发明名称 |
Camptothecin drug combinations and methods with reduced side effects |
摘要 |
This invention provides methods and combination formulations and kits to reduce the toxicity of camptothecin drugs, such as irinotecan (CPT-11). Disclosed are therapeutics and treatment methods employing such drugs in combination with agents that increase conjugative enzyme activity or glucuronosyltransferase activity, and agents that decrease biliary transport protein activity, such as cyclosporine A, the resultant effects of which are to decrease the significant side effects previously associated with treatment using these drugs.
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申请公布号 |
US5786344(A) |
申请公布日期 |
1998.07.28 |
申请号 |
US19950423641 |
申请日期 |
1995.04.17 |
申请人 |
ARCH DEVELOPMENT CORPORATION |
发明人 |
RATAIN, MARK J.;GUPTA, ELORA |
分类号 |
A61K45/00;A61K31/47;A61K45/06;(IPC1-7):A61K31/545 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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