| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject preparation good in storage stability, good in solubility in water for injection, easy in handling on administration by including a specific platinum (II) complex as a main ingredient. SOLUTION: This lyophilized preparation contains a platinum (II) complex of the formula (R<1> is a 1-3C lower hydrocarbon; R<2> , R<3> are each H, a 1-3C lower hydrocarbon; the configuration of the 1,2-diaminocyclohexane expresses cis-, trans-l-, or trans-d-1,2-diaminocyclohexane) as a main ingredient. The objective preparation is preferably obtained through a process for quickly freezing the solution [especially the concentration is 0.5-5(wt./vol)%] of a platinum (II) complex at a temperature of -50 to -30 deg.C and subsequently a process for drying the frozen product at two stages under a vacuum degree of 5-15 pascal and a vacuum degree of <=1.5 pascal, and has a water content of <=2.5wt.%. |
