发明名称 |
Hydrophilic, swellable coatings for biosensors |
摘要 |
Methods for reducing the electrode impedance of implantable biosensors by coating the surface of the biosensor with a uniform hydrogel which allows unimpeded water movement around the sensor are provided. The surface coatings are compositions which are biocompatible and are capable of water uptake of at least 120% of their weight, more preferably at least 200% of their weight. Upon the uptake of water, the hydrogels used in the present invention will also swell and provide a layer of water around the electrodes to which the hydrogels are attached. The hydrogels can be prepared from (a) a diisocyanate, (b) a hydrophilic polymer which is a hydrophilic diol, a hydrophilic diamine, or a combination thereof, and optionally, (c) a chain extender.
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申请公布号 |
US5786439(A) |
申请公布日期 |
1998.07.28 |
申请号 |
US19960749754 |
申请日期 |
1996.10.24 |
申请人 |
MINIMED INC. |
发明人 |
VAN ANTWERP, WILLIAM PETER;DECKER, CHRISTIAN C.;MASTROTOTARO, JOHN J. |
分类号 |
G01N27/327;A61B5/00;A61B5/145;C08G18/48;C08G18/61;C08G18/66;C08G77/458;C08J5/22;C12Q1/00;G01N27/40;G01N27/416;(IPC1-7):C08G18/72;B05D3/00 |
主分类号 |
G01N27/327 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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