The ability to convert daunorubicin to doxorubicin can be conferred on a host cell by transformation with a recombinant vector comprising DNA encoding daunorubicin 14-hydroxylase. The host cell can then be used to produce doxorubicin.
申请公布号
US5786190(A)
申请公布日期
1998.07.28
申请号
US19960760116
申请日期
1996.12.03
申请人
PHARMACIA & UPJOHN S.P.A.
发明人
INVENTI, AUGUSTO SOLARI;BREME, UMBERTO;COLOMBO, ANNA LUISA;HUTCHINSON, CHARLES RICHARD;OTTEN, SHAREE;SCOTTI, CLAUDIO
