DIMETHYLBENZOFURANS AND DIMETHYLBENZOPYRANES, THEIR USE AS 5-HT<SB>3</SB>-ANTAGONISTS, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION

摘要

FIELD: organic chemistry. SUBSTANCE: invention proposes new compounds of the general formula (I) 5-HT3 where and R are hydrogen or R and R form together bivalent radical: (a) -CH=CH-CH=C-; (b) -CH=C(Cl)-CH=CH- or (c) -CH= CH-C(Cl)=CH-; n = 2, 3 or 4; R - hydrogen or methoxy-group; m = 1 or 2; R - hydrogen, amino-group or R -alkylcarbonylamino-group; C1-C3 - hydrogen or halogen, their stereochemical isomers and intermediate products of synthesis of the formula (XIXa) R5- and levorotatory isomer of the formula (Ia) (). Invention proposes methods of synthesis of new compounds, pharmaceutical composition and an agent on the basis of compound of the general formula (I) that can be used in medicine for treatment of 5-R3= OCH3-mediated damages. EFFECT: improved method of synthesis of new compounds indicated above. 10 cl, 4 tbl