| 发明名称 |
SULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, METHOD OF INHIBITION OF FIBRIN EFFECT AND A METHOD OF TREATMENT OF MAMMALIAN WITH THROMBOSIS |
| 摘要 |
FIELD: organic chemistry. SUBSTANCE: products: derivatives of sulfonamide of the formula (I): <EMI ID=0.194 HE=33 WI=66 TI=CHI> where R - six-membered heterocycle with nitrogen atom or NR<SP>6</SP>R ; R<SP>6</SP>- - hydrogen; R - hydrogen or group of the formula <EMI ID=0.195 HE=9 WI=54 TI=CHI>; R =R is H; m = 4-6; n = 1; p = 0 or 1; R is -C<SB>1-10</SB>-alkyl, benzyl, styryl, phenyl, thienyl or substituted naphthyl; R is COOR ; R is H or methyl that are antagonists of IIb/IIIa-receptors of fibrinogen and inhibit platelet aggregation and benefit for prophylaxis and treatment of diseases caused by thromb formation. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 13 cl, 5 tbl-
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| 申请公布号 |
RU2116296(C1) |
申请公布日期 |
1998.07.27 |
| 申请号 |
RU19940041739 |
申请日期 |
1992.03.18 |
| 申请人 |
MERK EHND KO.INK. |
发明人 |
MELISSA S.EHGBERTSON;DZHORDZH D.KHARTMAN;VASIL' KHALSHCHENKO;VILL'JAM LEHSVELL;MARK E.DAGGAN |
| 分类号 |
C07D211/30;A61K31/185;A61K31/195;A61K31/215;A61K31/255;A61K31/265;A61K31/40;A61K31/4015;A61K31/41;A61K31/415;A61K31/42;A61K31/421;A61K31/435;A61K31/44;A61K31/4409;A61K31/4418;A61K31/4427;A61K31/4433;A61K31/445;A61K31/4465;A61K31/451;A61K31/452;A61K31/495;A61K31/496;A61K31/505;A61K31/55;A61K31/66;A61P7/02;A61P43/00;C07C311/02;C07C311/06;C07C311/13;C07C311/19;C07C313/06;C07C313/20;C07C323/59;C07C327/12;C07D207/08;C07D207/09;C07D207/10;C07D207/12;C07D207/26;C07D207/273;C07D209/12;C07D209/30;C07D211/18;C07D211/22;C07D211/32;C07D211/46;C07D213/75;C07D223/08;C07D233/02;C07D233/64;C07D237/08;C07D239/04;C07D239/26;C07D241/04;C07D241/12;C07D249/04;C07D249/08;C07D263/46;C07D267/10;C07D401/12;C07D401/14;C07D403/10;C07D403/12;C07D403/14;C07D409/12;C07D413/12;C07D413/14;C07D453/02;C07D453/06;C07D471/08;C07D487/08;C07F9/38;C07F9/40;(IPC1-7):C07D211/30 |
主分类号 |
C07D211/30 |
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