ANTIBODIES THAT BIND TO THE NIDOGEN-BINDING DOMAIN OF LAMININ, THEIR PRODUCTION AND USE

摘要

Monoclonal and polyclonal antibodies are disclosed as well as parts thereof which bind specifically to the nidogen-binding domain of laminin, as well as a process for producing the same and their use as medicaments, as diagnostic agents for detecting laminin isoforms and as model substances for developing and evaluating substances that influence the nidogen-laminin interaction. The disclosed antibodies or their parts bind preferably to the .gamma.1 III 4domain of laminin, in particular in the highly preserved area of loops a and c, and can inhibit the association of laminin and nidogen.