| 摘要 |
The present invention relates, in general, to a protein linked to cell respiration, thermogenesis, obesity and hyperinsulinemia and, in particular, to a protein designated uncoupling protein-2 (UCP2) and to nucleic acid sequences encoding same. The invention also relates to diagnostic methodologies based, for example, on a determination of levels of UCP2 expression. Further, the invention relates to therapies involving modulating UCP2 expression and/or activity. In addition, the present invention relates to methods of screening compounds for their suitability for use in such therapies.
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| 申请人 |
DUKE UNIVERSITY;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CENTRE DE RECHERCHE SUR L'ENDOCRINOLOGIE MOLECULAIRE ET LE DEVELOPPEMENT;SURWIT, RICHARD, S.;COLLINS, SHEILA, A.;WARDEN, CRAIG, H.;SELDIN, MICHAEL, F.;RICQUIER, DANIEL;BOUILLAUD, FREDERIC |
发明人 |
SURWIT, RICHARD, S.;COLLINS, SHEILA, A.;WARDEN, CRAIG, H.;SELDIN, MICHAEL, F.;RICQUIER, DANIEL;BOUILLAUD, FREDERIC |
