| 摘要 |
The present invention relates to compounds of the general formula <CHEM> wherein X is -O-, -NH-, -CH2-, -CH=, -CO2-, -CONH-, -CON(lower alkyl)-, -S- and -SO2-; R<1> - R<4> are, independently from each other hydrogen, halogen, hydroxy, amino, nitro, lower-alkyl-sulfonylamido, 1- or 2-imidazolyl, 1-(1,2,4-triazolyl) or acetamido; R<5>, R<6> are, independently from each other hydrogen, lower-alkyl, hydroxy, lower alkoxy or oxo; R<7>-R<10> are, independently from each other hydrogen, lower-alkyl, halogen, trifluoromethyl or lower-alkoxy; n is 0 or 1; and to pharmaceutically acceptable acid addition salts thereof. Compounds of the present invention are NMDA(N-methyl-D-aspartate)-receptor subtype selective blockers. |
