IMINE DERIVATES OF MADURAHYDROYLACTON, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS

摘要

The invention relates to imine derivatives of the madurahydroxylacton (3,9,11,14,15-pentahydroxy-7-methoxy-10-methyl-1,8,13-trioxo-1,3,5,6,8,13-hexahydronaphthaceno[1,2-f]isobenezofuran), with formula (I), and their pharmaceutically acceptable salts and esters. The invention also relates to a method for their production and pharmaceutical preparations containing these compounds. The compounds, in accordance with the invention, possess a non-steroidal backbone chain, display no estrogenous activity, have in the cell culture only slight cytotoxity, and are characterized in that they have a strong inhibitory effect on microsomal human placenta sulfatase.