发明名称 |
BIS-TETRAMERIC HEMOGLOBIN AND REAGENTS FOR ITS PRODUCTION |
摘要 |
Cross-linking reagents for protein modification are provided, which comprise four functional, leaving groups capable of reacting with amino acid residues on the protein chains, one pair at each end of a relatively rigid chemical spacer group comprising aromatic residues joined by amide linkages. Such crosslinking reagents react with hemoglobin to effect intramolecular cross-linking of two dimeric hemoglobin units to stabilize the tetramers, by use of the respective pairs of functional groups, and to produce dimers of such tetrameric units, i.e. bis-tetrameric, intramolecularly cross-linked and stabilized hemoglobin, to the exclusion of higher molecular weight hemoglobin species.
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申请公布号 |
CA2317836(A1) |
申请公布日期 |
1998.07.23 |
申请号 |
CA19982317836 |
申请日期 |
1998.01.13 |
申请人 |
LOCK-O'BRIEN, JODI J. L.;KLUGER, RONALD H. |
发明人 |
LOCK-O'BRIEN, JODI J. L.;KLUGER, RONALD H. |
分类号 |
C07C233/81;C07K14/805;(IPC1-7):C07K14/805 |
主分类号 |
C07C233/81 |
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地址 |
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