THF- gamma 2 analogs and pharmaceutical compositions comprising them

摘要

PCT No. PCT/US94/07304 Sec. 371 Date Mar. 29, 1996 Sec. 102(e) Date Mar. 29, 1996 PCT Filed Jun. 28, 1994 PCT Pub. No. WO95/01182 PCT Pub. Date Jan. 12, 1995The invention relates to analogs of thymic humoral factor gamma 2 (THF- gamma 2) having at least 4 amino acid residues and corresponding to the sequence of THF- gamma 2 of the formula I:Leu-Glu-Asp-Gly-Pro-Lys-Phe-LeuIbut differing therefrom by addition, deletion or substitution of one or more amino acid residues, or by cyclization, or by linkage of two or more sequences (I) or modified sequences (I) either directly or through a peptidic or non-peptidic chain. The THF- gamma 2 analogs of the invention and the functional derivatives and salts thereof are for use as immunomodulatory in pharmaceutical compositions.