发明名称 |
Chemical synthesis of 1,3-disubstituted quinazolinediones |
摘要 |
The present invention relates to a method for the synthesis of 1,3-disubstituted quinazolinedione derivatives which comprises: (a) reacting a haloformate functionalized polystyrene resin with a substituted anthranilic acid derivative under conditions effective to form a urethane-linkage; (b) reacting the product of step (a) with a primary amine under conditions effective to form an anthranilamide derivative; (c) heating the anthranilamide to effect intramolecular cyclization thereby liberating the 1,3-disubstituted quinazolinedione derivative from the resin into solution; and (d) isolating the 1,3-disubstituted quinazolinedione by filtration and solvent removal.
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申请公布号 |
US5783698(A) |
申请公布日期 |
1998.07.21 |
申请号 |
US19970779498 |
申请日期 |
1997.01.07 |
申请人 |
MERCK SHARP & DOHME LIMITED |
发明人 |
SMITH, ADRIAN LEONARD |
分类号 |
C07D239/96;(IPC1-7):C07D239/54 |
主分类号 |
C07D239/96 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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