发明名称 |
Solution containing IGF-1 |
摘要 |
PCT No. PCT/SE94/00010 Sec. 371 Date Oct. 16, 1995 Sec. 102(e) Date Oct. 16, 1995 PCT Filed Jan. 10, 1994 PCT Pub. No. WO94/15584 PCT Pub. Date Jul. 21, 1994The invention relates to solutions containing IGF-1 or any functional analogue thereof in which pH is 5.5 to 6.5, preferably 5.7 to 6.2. The amount of phosphate as buffer substance should be in a concentration of less than 50 mmol/L Preferably the formulation is an aqueous solution of IGF-1 and phosphate as buffer substance in a concentration of 5 to 50 mmole or more preferably 5-20 mmol/L, e.g. 10 mmol/L. The solution should be isotonic. The solution gives a reduced pain upon subcutaneous injection. The invention also relates to a process for preparation of the formulation by mixing IGF-1 or any functional analogue thereof with a buffer substance giving pH 5.5 to 6.5 and an isotonic agent. It also relates to a method for treatment of a patient in need of IGF-1 or any functional analogue thereof by administering the claimed formulation.
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申请公布号 |
US5783559(A) |
申请公布日期 |
1998.07.21 |
申请号 |
US19950491902 |
申请日期 |
1995.10.16 |
申请人 |
PHARMACIA & UPJOHN AKTIEBOLAG |
发明人 |
FLORIN-ROBERTSSON, EBBA;FRANSSON, JONAS;MOORE, DIANE |
分类号 |
A61K9/08;A61K9/00;A61K38/27;A61K38/30;A61K47/02;A61K47/24;(IPC1-7):A61K38/08;A61K38/22 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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