| 摘要 |
1308656 4-Chloro-carda-4,20(22)-dienolides FARBWERKE HOECHST AG 14 May 1970 [14 May 1969] 23473/70 Heading C2U The invention comprises 3-oxo-4-chloro-14#- hydroxycarda-4,20(22)-dienolide (V) and 3α,14#- or 3#,14#-dihydroxy -4 - chlorocarda - 4,20(22)- dienolide (VI), and their derivatives wherein one or more of the 1, 2, 6, 7, 11, 12 and 16- positions is substituted by an alkyl, acyl, C 1-3 acyloxy or ketalized oxo group. Preparation of the above is by the route: 3 - oxo - carda - 4,14,20(22) - trienolide # 3 - oxo - 4,14,15 - trichlorocarda - 4,20(22)- dienolide # 3 - oxo - 4 - chlorocarda - 4,14,20- (22) - trienolide # 3 - oxo - 4 - chloro - 14#- hydroxy - 15α - bromocarda - 4,20(22) - dienolide # V # VI. Pharmaceutical compositions comprise an inventive compound and a carrier. Compound V and its derivatives are said to be cardioactive, but no activity is specified for compound VI and its derivatives. Routes of administration are not specified. |
