Antibodies which bind to the nidogen-binding domain of laminin their preparation and use

摘要

The invention relates to monoclonal and polyclonal antibodies, and their parts, which bind specifically to the nidogen-binding domain of laminin, to processes for their preparation and to their use as pharmaceuticals, as diagnostic agents for detecting laminin isoforms and as model substances for developing and evaluating substances which affect the nidogen/laminin interaction. The antibodies according to the invention, or their parts, bind preferentially to the laminin gamma1 III 4 domain, in particular in the highly conserved region of the a and c loops, and are able to inhibit the association of laminin and nidogen.