发明名称 |
Stabilizers for lyophilized vaccines |
摘要 |
Vaccine stabilizers, vaccine formulations and lyophilized vaccines with enhanced thermostability are disclosed. The vaccine formulations comprise an increased amount of a 6-carbon polyhydric alcohol (such as sorbitol), an increased amount of a disaccharide (such as sucrose) and an amount of a physiologically active buffer to adjust the pH from about 6.0 to about 7.0. |
申请公布号 |
AU6013798(A) |
申请公布日期 |
1998.07.17 |
申请号 |
AU19980060137 |
申请日期 |
1997.12.18 |
申请人 |
MERCK & CO., INC. |
发明人 |
DAVID B. VOLKIN;CARL J. BURKE;SU-PI SHEU |
分类号 |
C12N7/04;A61K9/00;A61K9/08;A61K9/19;A61K39/00;A61K39/13;A61K39/165;A61K39/20;A61K39/245;A61K39/25;A61K39/29;A61K47/26;A61K47/42;A61P31/12 |
主分类号 |
C12N7/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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