| 摘要 |
Imidazole-4-butane-boronic acid derivatives of formula (I), in the form of pure enantiomers or enantiomer mixtures, and their acid addition salts are new. R1 = 1-4C alkyl, 3-8C cycloalkyl, phenyl (optionally substituted by halo, 1-5C alkyl, CF3, CN, COOMe or NHCOMe), phenyl-(1-4C)alkyl (optionally ring-substituted as for phenyl) or thienyl; R2, R'2 = H or 1-4C alkyl; R3 = H, COR4, COOR5, CONHR6, SO2R6, SO2NR7R8 or aralkyl, e.g. pyridinyl-(1-4C)alkyl or thienyl-(1-4C)alkyl; R4 = 1-4C alkyl; R5 = 1-4C alkyl or phenyl-(1-4C)alkyl; R6 = 1-5C alkyl, phenyl or phenyl-(1-5C)alkyl; R7, R8 = H or 1-4C alkyl; or NR7R8 = morpholino; X = O, S, CH2, SO2 or NR1; Y = H or 1-6C alkyl.
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