发明名称 |
CYTOKINE RELATED TREATMENTS OF DISEASE |
摘要 |
Nucleosides and other compounds to selectively modulate Th1 and Th2 responses relative to each other in the treatment of disease. In one aspect of the invention, administration of a nucleoside or other compound reduces the dosage at which a primary drug is administered. In another aspect of the invention, an abnormality reflected in increased response in one group of cytokines is treated by administering a nucleoside or other compound which increases response in another group of cytokines. In yet another aspect of the invention, a patient is prophylactically treated by administering a nucleoside or other compound which selectively reduces Th1 activity without significantly reducing Th2 activity. In yet another aspect of the invention, a nucleoside or other compound is administered to a patient at a dose which reduces the patient's GTP pool to a degree that selectively reduces one of the Th1 or Th2 response without significantly reducing the other response. Controlled release dosage forms are particularly contemplated to achieve that result.
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申请公布号 |
CA2278158(A1) |
申请公布日期 |
1998.07.16 |
申请号 |
CA19982278158 |
申请日期 |
1998.01.13 |
申请人 |
ICN PHARMACEUTICALS, INC. |
发明人 |
AVERETT, DEVRON;RAMASAMY, KANDASAMY;WANG, GUANGYI;TAM, ROBERT |
分类号 |
C07H19/167;A61K31/52;A61K31/522;A61K31/56;A61K31/70;A61K31/7042;A61K31/7052;A61K31/7056;A61K31/7076;A61K31/708;A61K31/7115;A61K45/06;A61P1/16;A61P3/10;A61P17/00;A61P31/12;A61P31/18;A61P35/00;A61P37/00;A61P37/04;A61P37/08;A61P43/00;C07H19/00;C07H19/04;C07H19/052;C07H19/056;C07H19/16;C07H19/24;(IPC1-7):A61K31/70 |
主分类号 |
C07H19/167 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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