发明名称 |
NOVEL HEDGEHOG-DERIVED POLYPEPTIDES |
摘要 |
The present invention provides two novel polypeptides, referred to as the "N" and "C" fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G &darr& CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.
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申请公布号 |
WO9830576(A1) |
申请公布日期 |
1998.07.16 |
申请号 |
WO1997US15753 |
申请日期 |
1997.10.07 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE;BEACHY, PHILIP, A.;PORTER, JEFFREY, A. |
发明人 |
BEACHY, PHILIP, A.;PORTER, JEFFREY, A. |
分类号 |
G01N33/53;A61K38/00;C07K14/435;C07K14/46;C07K14/47;C12N15/09;G01N33/50;G01N33/68;(IPC1-7):C07K1/00;C07K14/00;G01N33/567 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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