发明名称 |
NOVEL STAT FUNCTION-REGULATORY PROTEIN |
摘要 |
A protein regulating the functions of STAT proteins in the JAK/STAT signal transmission system in mammals characterized by being induced by STAT3 or STAT6, inhibiting the tyrosine phosphorylation of gp130 and STAT3 and having an SH2 region; a DNA encoding this protein; a method for screening substances having the function of regulating cytokines with the use of the above protein; the antisense DNA and RNA inhibiting the biosynthesis of the above protein; a monoclonal antibody capable of binding to the above protein; probe DNA and RNA hybridizable with the above DNA; a recombinant DNA constructed by integrating the above DNA into a vector allowing the replication thereof; the resultant transformant; and a method for screening substances having the function of regulating cytokines with the use of the above transformant.
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申请公布号 |
WO9830688(A1) |
申请公布日期 |
1998.07.16 |
申请号 |
WO1997JP03860 |
申请日期 |
1997.10.23 |
申请人 |
KISHIMOTO, TADAMITSU;NAKA, TETSUJI |
发明人 |
KISHIMOTO, TADAMITSU;NAKA, TETSUJI |
分类号 |
C07K14/47;C12N15/12;(IPC1-7):C12N15/12;C12Q1/68;C12Q1/02;C12N5/00;C12N21/08 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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