Antiadhäsive Sulfatid-Mimetika

摘要

Analogues of formula (I) of the so-called sulfatides (3-O-sulphated galactosyl ceramides) are disclosed in which the natural ceramide is substituted by a simple dialkylated unit. This aglycone may be O-, S- or C-glycosidically linked. These analogues may also contain several sulphate or other acid groups instead of just one such group. Also disclosed is the preparation of these compounds and their use for producing medicaments and diagnostic agents. In the formula (I), R<1>, R<2> independently represent -(CH2)n-CH3; n is an integer from 10 to 30; R<3>-R<6> independently represent OH, OSO3H, OCH2COOH, CH(COOH)2, O(CH2)2CH(COOH)2 or non-toxic salts of the corresponding acids, provided that at least one radical R<3>-R<6> be other than OH, and the hydroxy groups can be provided with protective groups such as benzyl, benzylidene or isopropylidene; and S stands for O, S, (CH2)2O or CH2O.