PROCEDIMIENTO PARA LA PREPARACION DE LAS NUEVAS ALCANODIOIL-BIS- (3-ACILAMINOMETIL-5-CARBOXI - 2,4,6-TRIYODO - ANILIDAS) APROPIADAS PARA LA UTILIZACION EN CALIDAD DE AGENTES DE CONTRASTE DE RAYOS X.

摘要

1,202,179. Acylamino derivatives of 2,4,6- triodo benzoic acid. BRACCO INDUSTRIA CHIMICA S.p.A. 1 April, 1969 [2 May, 1968], No. 17040/69. Heading C2C. [Also in Division A5] Novel compounds of the formula wherein alkylene denotes C 4-10 bivalent alkylene which may be interrupted by 2 or more O atoms, R is C 1-4 alkyl, preferably CH 3 or C 2 H 5 , and their non-toxic water-soluble metal and/or amine salts, are obtained by reacting an appropriate 3-acylaminomethyl-5-amino-2,4,6- triiodo benzoic acid with a reactive derivative of a dicarboxylic acid of formula HOOC- alkylene COOH, e.g. the acid chloride, mixed anhydride or a reactive ester thereof. The products may be converted into Na, Li, Ca, Mg, N-methyl glucamine, diethanolamine, morpholine or cyclohexylamine salts by conventional methods. The novel compounds are useful as X-ray contrast agents.