Novel pyrrolizine derivatives, their salts or solvates having anti-tumor activity, and processes for preparing them

摘要

The present invention relates to novel pyrrolizine derivatives of formula (1), their salts or their solvates, and relates to the use of the compounds as anti-tumor medicines or as site-specific DNA alkylating agents in the gene relating technologies, the compounds and their salts which are so soluble into water-soluble solvents and stable in bodies as to be capable of being used as anti-tumor medicines and in addition to this, can be so bound with the materials site-specifically bound with nucleic acid such as oligonucleotides, peptide analogs and cholesterols, as to be used in the gene relating technologies. In formula (1), R1, X, X', Y and n are the same as defined in the specification.