发明名称 |
Non-lethal conditioning methods for the treatment of acquired immunodeficiency syndrome |
摘要 |
The present invention relates to the use of a non-lethal preparative regimen for the treatment of a patient with human immunodeficiency virus (HIV) disease. In a clinical trial, an HIV-positive patient was conditioned by non-lethal doses of irradiation and a chemotherapeutic drug prior to receiving donor bone marrow cells from a baboon. While long-term engraftment of donor cells was not observed, the non-lethal preparative conditioning regimen was able to reduce the viral burden and improve the clinical outcome. Such method is useful for treatment of patients with advanced acquired immunodeficiency syndrome (AIDS). |
申请公布号 |
AU5382298(A) |
申请公布日期 |
1998.07.15 |
申请号 |
AU19980053822 |
申请日期 |
1997.12.12 |
申请人 |
ALLEGHENY UNIVERSITY OF THE HEALTH SCIENCES;CHIMERIC THERAPIES, INC. |
发明人 |
SUZANNE ILDSTAD;OLAV B. BERGHEIM |
分类号 |
A61K38/00;A61K41/00;C07K16/28 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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