| 摘要 |
<p>1,186,495. Fluorobenzoylpropyl - piperazines. DELALANDE S.A. 15 Jan., 1969 [20 Feb., 1968; 21 Feb., 1968], No. 2302/69. Heading C2C. Novel compounds of the formula wherein R represents a C 1-4 alkyl, optionally substituted by one or more free or esterified hydroxyl groups or by a primary, secondary or tertiary amine group, or an arylalkyl group containing not more than 10 carbon atoms, optionally substituted by a hydroxyl group, or a radical -(CH 2 ) n COOR<SP>1</SP> wherein n = 0, 1 or 2, and R<SP>1</SP> represents a C 1-4 aliphatic group, or a cycloaliphatic radical or an arylaliphatic radical, or R represents a pyrrolidinocarbonyl-methyl radical, are obtained by reacting together compounds of the formulµ wherein Hal represents a halogen atom and R is as above, at the reflux temperature of the medium in the presence of an appropriate organic solvent and an alkali which combines with the hydracid formed in the reaction. Pharmaceutical compositions having neuroleptical, hypotensive, antiserotonine, anti-emetic, anti-histaminic, and analgesic activity comprise a compound of Formula (1) above, together with a suitable carrier, in forms suitable for oral, rectal, parenteral or local administration.</p> |
