Immunization against (neisseria gonorrhoeae) and (neisseria meningitidis)

摘要

The present invention relates to a method of immunization against infection by a pathogenic Neisseria species. The method employs parenteral priming using a priming angiten, followed by oral immunization with gamma-irradiated, Protein III-deficient killed whole cells of Neisseria gonorrhoeae strain 340 or parenteral priming using a priming antigen followed by oral immunization with gamma-irradiated class 4 protein-deficient whole cells of Neisseria meningitidis. Also provided is a method for protecting a human patient against infection by N. meningitidis and N. gonorrhoeae comprising orally administering to the patient a protective amount of a class 4 protein-deficient, killed whole cell of N. meningitidis. In addition, the present invention provides a method for protecting a human patient against infection by N. meningitidis and N. gonorrhoeae comprising orally administering to the patient a protective amount of a class 4 protein-deficient, killed whole cell of N. meningitidis and an oral adjuvant.