| 摘要 |
This invention is directed to a novel protein of general significance to the cellular transport of nontransferrin bound iron. This heretofore unidentified protein, which is termed "stimulator of Fe (iron) transport" (SFT) protein, is essential to an alternative pathway of iron uptake. The cDNA encoding the SFT protein has been cloned and sequenced. The gene for the SFT protein has been mapped to chromosome 10, 17% of the distance from the centromere to the telomere of chromosome arm 10q, an area that corresponds to band 10q21. In addition, the amino acid structural identity of the SFT protein has been deduced, represented in a predicted transmembrane structure with a 6-transmembrane motif.
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